One of the main compounds purified from Centella asiatica total extract (Gotu Kola), Madecassoside is a natural and vegetable active ingredient with anti-inflammatory properties.
In countless tests, it has been proven that Madecassoside demonstrates a significant anti-inflammatory activity upon chronic skin inflammations. For one thing, it regulates IL1, IL8, PGE2 and SKALP (skin antileuco protease). For another, it normalises any disturbed proliferation of the keratinocytes and so, protects the cells against further inflammatory processes. The balance in the epidermis is restored. With the increase in collagen I and III synthesis, it also leads to a restructuring of the extracellular matrix of the dermis.