The plant Centella Asiatica is used in traditional medicine to treat a variety of disorders. The objective of this study presented in this report was to evaluate the wound healing potential of ethanolic extract of the plant in streptozotocin-induced diabetic rats. The study was carried out by using Wistar albino rats by creating excision and dead space wounds. The Centella Asiatica treated group’s measured wound area was reduced significantly compared to diabetic control animals. A significant increase in the weight of the granulation tissue and the hydroxyproline content was observed.
The histological study of the healing tissue obtained from the experimental diabetic animals showed the fast lay-down of collagen compared to the standard and diabetic control groups. The fasting blood glucose values of the diabetic experimental group animals were significantly reduced when compared to the diabetic control animals. We noticed a correlation between the wound contraction rate and the blood glucose values. The present study suggests that the oral administration of Centella Asiatica leaf extract may be useful in managing diabetic wounds due to its positive wound healing activity and hypoglycemic effects.
April – June 2013 RJPBCS volume 4, number 2 Page n ° 1082
Journal of Pharmaceutical Research, Biological and Chemical Evaluation of Centella Asiatica of Centella Asiatica Leaf Extract in the Wound Healing Process in Diabetic Rats by Sterptozotocin.
* B Somashekar Shetty and ** Sudhakar Pemmineti
* Department of Biochemistry, Melaka Manipal Medical College, Manipal Campus – India -576104
** Department of Pharmacology, American University of Antigua, West Indies.