A recent study, led at Korea Institute for Skin and Clinical Sciences in Seoul, has recently studied the protective effects of Centella Asiatica against ultraviolet B damages on skin.
In detail, this study aimed to evaluate the protective effects of Centella Asiatica against ultraviolet B (UVB) damage in human keratinocytes using microRNA (miRNA) expression profiling analysis.
Titrated extract of Centella Asiatica (TECA) demonstrated low cytotoxicity in normal human HaCaT keratinocytes only at low doses <5 µg/ml). While UVB (50 mJ/cm2) irradiation significantly decreased cell viability, TECA treatment decreased the UVB toxicity.
Using miRNA microarrays, the researchers determined that 72 miRNAs had an altered expression following TECA treatment in UVB-irradiated keratinocytes (46 upregulated and 26 downregulated). Using a miRNA target gene prediction tool and Gene Ontology (GO) analysis, it has been shown that miRNAs with altered expression were functionally related to the inhibition of apoptosis and cell proliferation.
Overall, the results of this study provide meaningful information to facilitate the understanding of TECA-mediated UVB protection in human keratinocytes.
An I.-S. et al., 2012. Centella Asiatica protects against UVB-induced HaCaT keratinocyte damage through microRNA expression changes. International Journal of molecular medicine, 30(6), pp.1349-1356.