Guided by the use of Centella Asiatica in Ayurvedic medicine to enhance memory and nerve function, a team of researchers from Portland, USA, led research on the potential use of Centella Asiatica in fighting Alzheimer’s Disease. This research has concluded that Centella Asiatica offers a unique therapeutic mechanism and novel active compounds of potential relevance to treating Alzheimer’s Disease.
In detail, a water extract of Centella Asiatica (Gotu Kola Water) attenuated Aβ-associated behavioural abnormalities in the Tg2576 mouse, a murine model of Alzheimer’s Disease. In vitro, Gotu Kola Water protected SH-SY5Y cells and MC65 human neuroblastoma cells from toxicity induced by exogenously added and endogenously generated Aβ, respectively. Aß.
Gotu Kola Water did not show anticholinesterase activity or protect neurons from oxidative damage and glutamate toxicity, mechanisms of current Alzheimer’s Disease therapies. The combination of data from in vitro and animal studies in the present work supports the Centella Asiatica potential for conferring clinical benefit in Alzheimer’s Disease, possibly by way of a novel mechanism of action.
Gotu Kola Water does not contain asiatic acid, a known Centella Asiatica neuroprotective triterpene, but is rich in phenolic compounds. Centella Asiatica may therefore contain novel active compounds of relevance to the treatment of Alzheimer’s Disease.
Soumyanath, A. et al., 2012. Centella Asiatica Extract Improves Behavioral Deficits in a Mouse Model of Alzheimer’s Disease: Investigation of a Possible Mechanism of Action. International Journal of Alzheimer’s Disease, 2012, pp.1–9.