Centella and its Cosmetic applications

Collagen synthesis stimulating activity

The active ingredients of Centella asiatica have shown to have modulating properties on the development and metabolism of connective tissue.

Centella asiatica has been documented to aid wound healing in several scientific studies. One of the primary mechanisms of action of this plant appears to be the stimulation of type-1 collagen production. Animal studies have consistently shown topical application of Centella asiatica to a sutured wound significantly increased the breaking strength of the wound.

Thus, selected triterpenes of Centella asiatica may help to improve wound repair with a better re-epithelialisation and a normalisation of perivascular connective tissue allowing an improvement of the venous wall tone and elasticity.

 

Activity on vascular tone

Rigorous clinical investigation of Centella asiatica has been conducted on chronic venous insufficiency and varicose veins. Centellahas the potential to enhance connective tissue integrity, elevate antioxidant levels in wound healing, and improve capillary permeability.

Mucoploysaccharides are one of the main components of the amorphous cellular matrix (ground substance) that maintains vascular integrity. The biochemical action of Centellaextract was shown to reduce serum levels of lysosomal enzymes involved in the degradation of mucopolysaccharides considering as an evidence of the positive effect of Centella extract on the pathogenesis of varicose veins.

According to the different studies done we can consider that Centellaextract is recommendable to formulate cosmetic products with vessel protection, venotonic and anti-cellulite activities.

 

Antioxidant activity

Several studies have shown that oral treatment with extracts of Centella Asiaticacan improve the activities of antioxidant enzymes and slow down the oxidative stress process.

Thus, Centella Asiatica extract is recommendable to formulate cosmetic products for the protection of skin and hair against oxidative processes.

 

 

Effects/Uses table

Effects

Cosmetic Uses

Stimulates healing of wounds, sores, eczema, ulcers, infected cuts & other skin ailments 1,2,3,4,6,7,9,13

Stimulates collagen synthesis 12

Prevention of scarring3

Treatment of keyloid & hypertrophied scars 3,13

Anti-inflammatory2,3,4,7

Anti-irritant6,7

Soothing6

Analgesic4

Product dedicated for damaged and chapped skin

After sun creams6

Promotes keratinisation and healthy growth of the recticulo-endothelium (skin & underlying connective tissue)

Improves tensile strength of tissue, when applied topically4,7,9

Skin care especially anti-ageing products and products for mature skins

Eye contour creams

Antiseptic6

Cleansing wounds2,8

Purifying6

Anti-acne products and products for blemished, problem & adolescent skins
Anti-cellulite13

Anti-oedema6

Diuretic2,7

Circulatory stimulant14

Peripheral vasodilator6

Anti-cellulite, skin firming and contouring products & creams for massage & “heavy legs”
Skin smoothing6

Tonic8

Bath & shower products

 

Références bibliographiques

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