积雪草提取物的健康目标
积雪草提取物的医疗保健用途非常广泛,范围从加速瘢痕形成到麻风病缓解。
静脉功能不全和静脉曲张
积雪草的最大药用功效在于治疗慢性静脉功能不全,静脉曲张。在这种情况下,血液汇聚在腿部,造成酸疼,沉重,肿胀,疲劳,和难看的可见静脉。初步的双盲安慰剂对照研究表明,积雪草提取物能改善静脉功能不全的症状,主要减少肿胀、疼痛、疲劳,感觉沉重,和静脉的流体泄漏 [1,2,3,4,5,6,7].
以其在阿育吠陀医学中的药用特性而闻名
康复
静脉曲张
失眠
认知功能

伤口愈合和皮肤损伤
积雪草提取物已被用于传统的伤口愈合—研究越来越支持这些说法8。 积雪草中含有三萜类化合物,主要有积雪草苷和羟基,可以强化肌肤,对伤口增加血液供应,提高伤口的抗氧化活性。据报道积雪草苷通过对促进胶原蛋白的形成和血管生形成9,10恢复皮肤弹性和精致度来加强伤口愈合 [11,12]。
愈合凝胶产品很突出。其对角化的影响,有助于增厚感染区的皮肤 [13]。

积雪草制剂也可能是有助于减少妊娠纹(妊娠纹)。一项对100例孕妇的安慰剂对照研究中把含有积雪草提取物,维生素E(α-生育酚),和胶原蛋白水解物的乳霜当做一种安慰剂[14]。复合乳霜比安慰剂更能减少缓和妊娠纹。
积雪草制剂的应用可能有助于在伤口愈合过程中减少可见伤疤,增加I型胶原蛋白,减少炎症反应和肌成纤维母细胞 [15]。
失眠 镇静
在许多东方文化中积雪草常被用镇静剂,主要贡献在玻热模甙和玻热米苷成分16。一项双盲安慰剂对照研究积雪草在人体的抗焦虑活性 [17]。
作者认为,这些研究结果表明,积雪草对人类有抗焦虑活性,这种抗焦虑活性可能由于囊素受体和胆碱能增强。

记忆 认知功能
一些实验室的研究发现,积雪草提取物有助于减少老鼠在阿尔茨海默氏病(AD)模型的认知障碍和刺激海马区神经元树突属性 [18]。
神经保护作用的机制包括环腺苷酸的磷酸化作用的增强, 来响应蛋白元素的结合(CREB)和ERK / PSK信号通路的抑制。一个对健康志愿者安慰剂对照随机双盲研究发现,积雪草提取物可改善老年人认知功能和调节积极情绪 [19]。

焦虑
三萜类化合物似乎能减少老鼠的焦虑和增加心智功能。有一个人的研究发现,谁服用积雪草比服用安慰剂会更不容易受噪音惊吓。 “震惊的噪声”可以是焦虑的一个指标,研究人员认为,积雪草可能有助于减少焦虑症状。但在这项研究中使用的剂量是非常高的,所以这很难说有积雪草可以用来治疗焦虑。
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