积雪草提取物的健康目标

积雪草提取物的医疗保健用途非常广泛，范围从加速瘢痕形成到麻风病缓解。

静脉功能不全和静脉曲张

积雪草的最大药用功效在于治疗慢性静脉功能不全，静脉曲张。在这种情况下，血液汇聚在腿部，造成酸疼，沉重，肿胀，疲劳，和难看的可见静脉。初步的双盲安慰剂对照研究表明,积雪草提取物能改善静脉功能不全的症状,主要减少肿胀、疼痛、疲劳,感觉沉重,和静脉的流体泄漏 [1,2,3,4,5,6,7].

以其在阿育吠陀医学中的药用特性而闻名

康复
静脉曲张
失眠
认知功能

伤口愈合和皮肤损伤

积雪草提取物已被用于传统的伤口愈合—研究越来越支持这些说法8。积雪草中含有三萜类化合物，主要有积雪草苷和羟基，可以强化肌肤，对伤口增加血液供应，提高伤口的抗氧化活性。据报道积雪草苷通过对促进胶原蛋白的形成和血管生形成9,10恢复皮肤弹性和精致度来加强伤口愈合 [11,12]。

愈合凝胶产品很突出。其对角化的影响，有助于增厚感染区的皮肤 [13]。

积雪草制剂也可能是有助于减少妊娠纹（妊娠纹）。一项对100例孕妇的安慰剂对照研究中把含有积雪草提取物，维生素E（α-生育酚），和胶原蛋白水解物的乳霜当做一种安慰剂[14]。复合乳霜比安慰剂更能减少缓和妊娠纹。

积雪草制剂的应用可能有助于在伤口愈合过程中减少可见伤疤，增加I型胶原蛋白，减少炎症反应和肌成纤维母细胞 [15]。

失眠镇静

在许多东方文化中积雪草常被用镇静剂，主要贡献在玻热模甙和玻热米苷成分16。一项双盲安慰剂对照研究积雪草在人体的抗焦虑活性 [17]。

作者认为，这些研究结果表明，积雪草对人类有抗焦虑活性，这种抗焦虑活性可能由于囊素受体和胆碱能增强。

记忆认知功能

一些实验室的研究发现，积雪草提取物有助于减少老鼠在阿尔茨海默氏病（AD）模型的认知障碍和刺激海马区神经元树突属性 [18]。

神经保护作用的机制包括环腺苷酸的磷酸化作用的增强，来响应蛋白元素的结合（CREB）和ERK / PSK信号通路的抑制。一个对健康志愿者安慰剂对照随机双盲研究发现，积雪草提取物可改善老年人认知功能和调节积极情绪 [19]。

焦虑

三萜类化合物似乎能减少老鼠的焦虑和增加心智功能。有一个人的研究发现，谁服用积雪草比服用安慰剂会更不容易受噪音惊吓。 “震惊的噪声”可以是焦虑的一个指标，研究人员认为，积雪草可能有助于减少焦虑症状。但在这项研究中使用的剂量是非常高的，所以这很难说有积雪草可以用来治疗焦虑。

Bibliographical references

[1] Cesarone MR, et al. The Microcirculatory Activity of Centella asiatica in Venous Insufficiency. A Double-blind Study. Minerva Cardioangiol. 1994;42(6):299-304.

[2] Allegra C. Comparative Capillaroscopic Study of Certain Bioflavonoids and Total Triterpenic Fractions of Centella asiatica in Venous Insufficiency. Clin Ter. 1981;99:507-13.

[3] Tenni R, et al. Effect of the Triterpenoid Fraction of Centella asiatica on Macromolecules of the Connective Matrix in Human Skin Fibroblast Cultures. Ital J Biochem. 1988;37(2):69-77.

[4] Darnis F, et al. Use of a Titrated Extract of Centella asiatica in Chronic Hepatic Disorders. Sem Hop. 1979;55(37-38):1749-50.

[5] Cesarone MR, Laurora G, De Sanctis MT, et al. Activity of Centella asiatica in Venous Insufficiency. Minerva Cardioangiol. Apr1992;40(4):137-43.

[6] Belcaro GV, Grimaldi R, Guidi G. Improvement of Capillary Permeability in Patients with Venous Hypertension after Treatment with TTFCA. Angiology. Jul1990;41(7):533-40.

[7] De Sanctis MT, Incandela L, Cesarone MR, et al. Acute Effects of TTFCA on Capillary Filtration in Severe Venous Hypertension. Panminerva Med. Jun1994;36(2):87-90.

[8] Brinkhaus B, Lindner M, Schuppan D, et al. Chemical, Pharmacological and Clinical Profile of the East Asian Medical Plant Centella asiatica. Phytomedicine. Oct2000;7(5):427-48.

[9] Rosen H, Blumenthal A, McCallum J. Effect of Asiaticoside on Wound Healing in the Rat. Proc Soc Exp Biol Med. May1967;125(1):279-80.

[10] Kimura Y, Sumiyoshi M, Samukawa K, Satake N, Sakanaka M. Facilitating action of asiaticoside at low doses on burn wound repair and its mechanism. Eur J Pharmacol. 28 Apr 2008;584 (2-3):415-423. Epub 21 Feb 2008.

[11] Sunilkumar, Parameshwarajah S, Shivakumar HG. Evaluation of Topical Formulations of Aqueous Extract of Centella asiatica on Open Wounds in Rats. Indian J Exp Biol. Jun1998;36(6):569-72.

[12] Shukla A, Rasik AM, Dhawan BN. Asiaticoside-induced Elevation of Antioxidant Levels in Healing Wounds. Phytother Res. Feb1999;13(1):50-4.

[13] Poizot A, et al. Modification of the Kinetics of Healing after Iterative Exeresis in the Rat. Action of a Triterpenoid and Its Derivatives on the Duration of Healing. C R Acad Sci Hebd Seances Acad Sci D. 1978;286(10):789-92.

[14] Young GL, Jewell D. Creams for Preventing Stretch Marks in Pregnancy. Cochrane Database Syst Rev. 2000;(2):CD000066.

[15] Widgerow AD, Chait LA, Stals R, et al. New Innovations in Scar Management. Aesthetic Plast Surg. May2000;24(3):227-34.

[16] Ramaswamy AS, et al. Pharmacological Studies on Centella asiatica. Linn. J Res Indian Med. 1970;4:160-75.

[17] Bradwejn J, Zhou Y, Koszycki D, et al. A Double-blind, Placebo-controlled Study on the Effects of Gotu Kola (Centella asiatica) on Acoustic Startle Response in Healthy Subjects. J Clin Psychopharmacol. Dec2000;20(6):680-4.

[18] Xu Y, Cao Z, Khan I, Luo Y. Gotu Kola (Centella asiatica) extract enhances phosphorylation of cyclic AMP response element binding protein in neuroblastoma cells expressing amyloid beta peptide. J Alzheimers Dis. Apr 2008;13(3):341-349.

[19] Wattanathorn J, Mator L, Muchimapura S, et al. Positive modulation of cognition and mood in the healthy elderly volunteer following the administration of Centella asiatica. J Ethnopharmacol. 5 Mar 2008;116(2):3

积雪草提取物的健康目标