TECA – 选定性三萜类化合物

名称: TECA (滴定积雪草提取物)
N° CAS: 84696-21-9
N° CTFA:  
N° EINECS:  
滴定法: 积雪草苷 36%-44%
自由配基(积雪草酸 & 羟基积雪酸) 54%-66%

Titrated extract of centella asiatica - molecular structure hand drawn

 


 

TECA,也称为选择性积雪草三萜,是一种高纯度的提取物,在达到约40%的积雪草苷和约60%三萜配基(积雪草酸和羟基积雪草酸的酸)时分级富含三萜酸和三萜糖酯馏分。

极致的纯化步骤和涉及移除草药矩阵的化学处理方式,使最终的提取物是一种以单独的成分和还没有维持自然比例的成分的复合的高度精制的提取物 。

 

TECA 的属性

TECA的生物活性在以下3个主要领域是有效的:

- 主要通过加强血管壁改善微循环,同时也可减少水肿。

- 通过刺激I型胶原合成和抗基质金属蛋白酶(MMPs)促进真皮重建。

- 减少和预防妊娠纹。

 

TECA的应用

- 医疗的应用 (静脉功能不全1 2 ,静脉高血压性血管病3 4, ,航班微血管病 5 ;

-化妆品的应用(推荐剂量的0.5%):

  • 真皮重建
  • 微循环活化
  • 妊娠纹的预防 & 治疗
  • 抗衰老
  • 皮肤修复

References

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1 Pointel JP, Boccalon H, Cloarec M, et al. Titrated extract of Centella asiatica (TECA) in the treatment of venous insufficiency of the lower limbs. Angiology 1987;38:46-50. LINK

2 Cesarone MR, Laurora G, et al. [The microcirculatory activity of Centella asiatica in venous insufficiency. A double-blind study]. Minerva Cardioangiol 1994 Jun;42(6):299-304.

3 Cesarone MR, Belcaro G, De Sanctis MT, et al. Effects of the total triterpenic fraction of Centella asiatica in venous hypertensive microangiopathy: a 67. Centella asiatica prospective, placebo-controlled, randomized trial. Angiology 2001;52:S15-S18. LINK

4 Cesarone MR, Belcaro G, Rulo A, et al. Microcirculatory effects of total triterpenic fraction of Centella asiatica in chronic venous hypertension: measurement by laser Doppler, TcPO2-CO2, and leg volumetry. Angiology 2001;52:S45-S48. LINK

5 Cesarone MR, Incandela L, De Sanctis MT, et al. Flight microangiopathy in medium- to long-distance flights: prevention of edema and microcirculation alterations with total triterpenic fraction of Centella asiatica. Angiology 2001;52:S33-S37. LINK

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Technical Data Sheet

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