TECA – Selected triterpenes

Name: TECA (Titrated Extract of Centella Asiatica)
N° CAS: 84696-21-9
N° CTFA:  
N° EINECS:  
Titration: Asiaticoside 36%-44%
Free genines (Asiatic acid & madecassic acid) 54%-66%

Titrated extract of centella asiatica - molecular structure hand drawn

 


 

TECA, also called Selected Centella Triterpenes, is a highly purified extract, fractioned and enriched in triterpenic acid and triterpenic sugar ester fractions to reach about 40% of asiaticoside and about 60% of the triterpenic genins (asiatic acid and madecassic acid).

The purification steps are extreme and involve chemical treatments that remove the herbal matrix so that the final extract is a recombination of a highly refined extract with an isolated constituent and the natural proportion of the components is not maintained.

 

TECA properties

TECA biological activities show to be efficient in 3 main domains :

- Improve microcirculation mainly by reinforcing vessels’ walls. This characteristic permits also to reduce Oedema.

- Promote dermis reconstruction by stimulating collagen I synthesis and protecting against matrix metalloproteinases (MMPs).

- Act on stretchmarks reduction and prevention.

 

TECA applications

- Medical use (venous Insufficiency 1 2 , venous hypertensive angiopathy 3 4, airline flight microangiopathy 5 ;

- Cosmetic application (0.5% for recommended dosage):

  • Dermis reconstruction
  • Microcirculation activation
  • Stretchmarks prevention & Treatment
  • Anti-aging
  • Skin repair

References

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1 Pointel JP, Boccalon H, Cloarec M, et al. Titrated extract of Centella asiatica (TECA) in the treatment of venous insufficiency of the lower limbs. Angiology 1987;38:46-50. LINK

2 Cesarone MR, Laurora G, et al. [The microcirculatory activity of Centella asiatica in venous insufficiency. A double-blind study]. Minerva Cardioangiol 1994 Jun;42(6):299-304.

3 Cesarone MR, Belcaro G, De Sanctis MT, et al. Effects of the total triterpenic fraction of Centella asiatica in venous hypertensive microangiopathy: a 67. Centella asiatica prospective, placebo-controlled, randomized trial. Angiology 2001;52:S15-S18. LINK

4 Cesarone MR, Belcaro G, Rulo A, et al. Microcirculatory effects of total triterpenic fraction of Centella asiatica in chronic venous hypertension: measurement by laser Doppler, TcPO2-CO2, and leg volumetry. Angiology 2001;52:S45-S48. LINK

5 Cesarone MR, Incandela L, De Sanctis MT, et al. Flight microangiopathy in medium- to long-distance flights: prevention of edema and microcirculation alterations with total triterpenic fraction of Centella asiatica. Angiology 2001;52:S33-S37. LINK

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Technical Data Sheet

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